YAMASA CORPORATION Biochemicals Division

YAMASA CORPORATION Biochemicals Division


YAMASA CORPORATION Biochemicals Division



Yamasa manufactures small molecular active pharmaceutical ingredients (APIs) of nucleic acid related compounds. Yamasa provides APIs for new drugs at all stage from R&D to commercial, and for generic drugs.
In addition to the listed products which are examples of APIs for generic drugs, we are manufacturing other APIs.


Mizoribine is an immunosuppressive drug which is applied for prevention of renal transplant rejection, lupus nephritis, and rheumatoid arthritis.


Vidarabine is an anti-virus drug which is applied for herpes simplex and herpes zoster.

Product name Synonym Structure
Mizoribine Mizoribine
Vidarabine Vidarabine


Therapeutic oligonucleotides are composed of modified nucleoside monomers. Yamasa provides the modified monomers and offers custom synthesis of oligomers. In addition to existing monomers including LNA amidites, Yamasa can collaborate in developmnt of new monomers.

Product name Synonym Structure
LNA-T Phosphoramidite LNA-T Phosphoramidite
LNA-A(Bz) Phosphoramidite LNA-A(Bz) Phosphoramidite
LNA-G(dmf) Phosphoramidite LNA-G(dmf) Phosphoramidite
LNA-5-MeC(Bz) Phosphoramidite LNA-5-MeC(Bz) Phosphoramidite

Materials used for mRNA synthesis

Yamasa provides the materials used for synthesis of mRNA. Yamasa has been providing high quality Pseudouridine used for mRNA COVID-19 vaccines in commercial scale.

Product name Synonym Structure
5-Methylcytidine 5'-triphosphate, solution 5-Me-CTP
1-Methylpseudouridine 1-Me-Pseudouridine
1-Methylpseudouridine 5'-triphosphate, solution 1-Me-Pseudo-UTP
Pseudouridine Pseudouridine
Pseudouridine 5'-triphosphate, solution Pseudo-UTP


Yamasa offers nucleic acid related compounds as pharmaceutical intermediates and industrial products obtained by chemical or enzymatic synthesis of each nucleotide.
Nucleotides are used as intermediates of APIs, food additives, and cosmetic ingredients. These days, nucleotides are globally used as key ingredients for infant formula. Yamasa manufactures high quality nucleotides for food additives under ISO 9001.

Product name Synonym Structure
Adenosine Adenosine
Adenosine 5'-monophosphate, disodium salt 5'-AMP, 2Na
Adenosine 5'-monophosphate, free acid 5'-AMP, free
Cytidine Cytidine
Cytidine 5'-diphosphate, trisodium salt 5'-CDP, 3Na
Cytidine 5'-monophosphate, disodium salt 5'-CMP, 2Na
Cytidine 5'-monophosphate, free acid 5'-CMP, free
2'-Deoxyadenosine 5'- triphosphate, solution dATP
2'-Deoxycytidine 5'- triphosphate, solution dCTP
2'-Deoxyguanosine 5'- triphosphate, solution dGTP
2'-Deoxythymidine 5'- triphosphate, solution dTTP
Guanosine 5'-monophosphate, disodium salt 5'-GMP, 2Na
Inosine 5'-diphosphate, trisodium salt 5'-IDP, 3Na
Inosine 5'-monophosphate, disodium salt 5'-IMP, 2Na
Uridine Uridine
Uridine 5'-diphosphate, disodium salt 5'-UDP, 2Na
Uridine 5'-monophosphate, disodium salt 5'-UMP, 2Na
Xanthosine Xanthosine
3’-Phosphoadenosine 5’-Phosphosulfate Sodium Salt PAPS

Sugar nucleotides

Sugar nucleotides are the substances made of nucleotide and sugar. Sugar nucleotides are the activated forms of monosaccharides acting as glycosyl donors.Sugar nucleotides play a role as substrates in the enzymatic synthesis of oligosaccharides. For example, sugar nucleotides are used for glycosylation modification to biopharmaceutical.
Yamasa supplies 8 types of sugar nucleotides with high quality which can be used for glycoengineering by enzymatic synthesis technology.

Product name Synonym Structure
Cytidine 5'-monophospho-N-acetylneuraminic acid disodium salt CMP-NeuAc, 2Na
Guanosine 5'-diphosphofucose, disodium salt GDP-Fuc, 2Na
Guanosine 5'-diphospho-D-mannose, disodium salt GDP-Man,2Na
Uridine 5'-diphospho-N-acetylglucosamine, disodium salt UDP-GlcNAc, 2Na
Uridine 5'-diphospho-N-acetylgalactosamine, disodium salt UDP-GalNAc, 2Na
Uridine 5'-diphosphogalactose, disodium salt UDP-Gal, 2Na
Uridine 5'-diphosphoglucose, disodium salt UDP-Glc, 2Na
Uridine 5'-diphosphoglucuronate, trisodium salt UDP-GlcUA, 3Na


STING ligands typified by cyclic di-AMP are actively studied for use in various vaccine therapies including cancer immunotherapy. Yamasa can supply high-quality cyclic di-AMP with controlled endotoxin level. Yamasa also supply Poly(I:C), an excellent TLR3-acting adjuvant, with controlled chain-length.

Product name Synonym Structure
3’,5’-Cyclic diadenylic acid, disodium salt c-di-AMP, 2Na
3',5'-Cyclic diguanylic acid c-di-GMP
Polycytidylate, sodium salt Poly (C), Na
Polyinosinate, sodium salt Poly (I), Na
Polyinosinate Polycytidylate, sodium salt Poly (I)・Poly(C), Na

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